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  Citation statistics : Table of Contents
   2012| May-June  | Volume 4 | Issue 3  
    Online since July 17, 2017

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In vivo antiplasmodial activity of byrsocarpus coccineus leaf extract in mice infected with plasmodium berghei
Joseph L Akpan, Godwin C Akuodor, BC Ezeokpo, AD Essien, AC Bassey, J.O.C Ezeonwumelu
May-June 2012, 4(3):78-83
Objective: To investigate the in vivo antiplasmodial activity of ethanolic leaf extract of Byrsocarpus coccineus in mice infected with Plasmodium berghei. Methods: Curative effect against established infection and suppressive activity against early infection were screened. Results: The extract (100,200 and 400 mg/kg, p.o.) has significant (p<0.05) dose dependent activity against the parasites in the curative and suppressive tests. The extract also prolonged the survival time of the infected mice. The oral LD50 values were greater than 5000 mg/kg in mice. Conclusion: The result shows that the extract possesses considerable antiplasmodial activity which can be exploited in malaria therapy.
[ABSTRACT]   Full text not available  [PDF] [CITATIONS]
  5 834 163
The reporting of blood and body fluid exposure and follow-up practices in a tertiary care hospital in the United Arab Emirates
Moazzam Ali Zaidi, Robin F Griffiths, Peter D Larsen, Mark Newson-Smith, Mukarram Ali Zaidi
May-June 2012, 4(3):84-89
The study explored the reporting and follow-up practices after blood and body fluid exposures in a tertiary care hospital in the United Arab Emirates. The Occupational Health Clinic schedule was audited, and medical files of staff members visiting the Clinic to report an exposure during 2006 and 2007 were retrieved for a detailed review. The raw data were obtained and analyzed; the original files were used as a reference to recover any missing information. Results showed that 156 exposures were reported; of which 77.6% were needle stick injuries. These were most commonly caused by handling, passing, disposing of needles, or while manipulating the needle in the patient. Hospital Wards were the most common location from which exposures were reported (41%). Nurses reported 61% of the exposures, followed by physicians 24%, laboratory staff 9%, and others 6%. Blood analysis was performed for 63% of patients to whose blood staffs were exposed. Post exposure blood tests were performed on 91% of staff. Treatment and follow-up was traced for 6 months at which 42.3% of the staff did not complete the follow-up. The retrospective clinical audit showed that the reported exposures were not managed properly. Repeated preventable exposures were being reported which involved exposures related to recapping and disposal. We recommend a comprehensive blood and body fluid programme to improve the safety and quality of work at the hospital.
[ABSTRACT]   Full text not available  [PDF]
  - 733 94
Interplay of insulin resistance and the reproductive and metabolic changes in women with polycystic ovary syndrome
Asmaa F Hassan, Omyma G Ahmed, Marwa A Ahmed, Hosam O Hamed
May-June 2012, 4(3):90-98
Background: Polycystic ovary syndrome (PCOS) is a complex reproductive, endocrine-metabolic disorder with insulin resistance (IR) as a common feature. Objective: To clarify whether IR and associated hyperinsulinemia play a key role in the pathophysiological changes in PCOS especially, reproductive and metabolic changes, and the efficacy of metformin therapy in these cases. Patients and Methods: Twenty five PCOS patients received metformin 850 mg twice daily for four months and fifteen healthy controls were included in this study. Body mass index (BMI) evaluation followed by ultrasound examination for measurement of antral follicle count (AFC) in both ovaries, oral glucose tolerance test (OGTT), fasting blood glucose, insulin and glucose / insulin ratio (G/I) were measured in addition to serum total testosterone (T), luteinizing hormone (LH) and insulin like growth factor-1 (IGF-1) estimation for all subjects. These parameters were re-evaluated again 4 months after metformin treatment was initiated in PCOS patients. Results: PCOS patients had significantly increased fasting blood glucose levels (P < 0.05), BMI, T, IGF-1 (P < 0.01), LH, insulin levels and AFC (P < 0.001) but G/I ratio was significantly (P < 0.001) lower in comparison to controls. Significant negative correlations between fasting G/I ratio and each of BMI, T, and AFC respectively were evident. Impaired OGTT at baseline was observed in PCOS patients with significant improvement noted after initiation of metformin therapy. Metformin significantly decreased BMI, serum T, LH, IGF-1 levels and AFC and increased the G/I ratio versus pretreatment values. Conclusion: IR plays a vital pathophysiological role in PCOS patients as manifested by causal relationship between insulin resistance and the reproductive and metabolic changes of PCOS. Metformin potentially improves these changes.
[ABSTRACT]   Full text not available  [PDF]
  - 698 76
The EKG Quiz: “Suspicious!”
Fathi Idris Ali
May-June 2012, 4(3):99-102
Full text not available  [PDF]
  - 428 91
A surfacing problem
Howard H Chan, Anthony K Chan, Keith K Lau
May-June 2012, 4(3):103-105
Full text not available  [PDF]
  - 416 113
Identification and reporting of common hemoglobin disorders: A review
Jessica A Hemminger, Nazih AbuAlsheikh, Samir B Kahwash
May-June 2012, 4(3):63-77
Hemoglobinopathies and thalassemias constitute a major cause of anemia worldwide. Some of these disorders may necessitate chronic red blood cell transfusion therapy, which frequently results in a host of serious clinical sequelae, including iron overload. The following review attempts to offer a simplified approach to the identification of the most commonly encountered hemoglobin disorders. In addition, practical comments on reporting the results of hemoglobin studies and the expected clinical impact of the various findings are discussed.
[ABSTRACT]   Full text not available  [PDF]
  - 702 98