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   2010| May-June  | Volume 2 | Issue 3  
    Online since July 18, 2017

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In vivo schizonticidal activity of ethanolic leaf extract of gongronema latifolium on plasmodium berghei berghei in mice
GC Akuodor, Maryam Idris-Usman, Theresa C Ugwu, JL Akpan, SI Ghasi, UA Osunkwo
May-June 2010, 2(3):118-124
In vivo schizonticidal activity of ethanolic leaf extract of Gongronema latifolium on blood-borne chloroquine- sensitive Plasmodium berghei berghei in mice was determined so as to scientifically justify the traditional use of the plant in south eastern Nigeria (tropical rain forest region) for local management of malaria fevers. The ethanolic leaf extract of Gongronema latifolium (200 - 800mg/kg) was administered orally to mice during early and established Plasmodium berghei berghei infections and its repository action in blood was also determined. The leaf extract at these doses caused 71-81% inhibition of parasitemia in the suppressive test, 59-73% parasitemia inhibition in the repository test and a mean survival time of 25-29 days in the curative test. These results show significant (P<0.05) antiplasmodial activity in the four-day suppressive test and in the curative test. These findings support the traditional use of the leaf extract of Gongronema latifolium for local treatment of malaria.
[ABSTRACT]   Full text not available  [PDF] [CITATIONS]
  1,122 133 3
Non-communicable diseases and diabetes care guidelines: Epidemiology and call for collective action. February, 6th 2010, dat elmad conference hall complex, Tripoli, Libya
Salem A Beshyah
May-June 2010, 2(3):142-148
On February 6, 2010, over 500 health care professionals gathered in Tripoli, Libya to witness two major National Health Service achievements related to the evaluation and combating the burden of non-communicable diseases. The results of the first national non-communicable diseases (STEPwise) survey were revealed and the first national diabetes care guidelines were launched. These were the fruit of collaboration of the government departments and their agencies, non-government organizations, regional and international organizations, and national scientific societies. The survey results showed an alarmingly high prevalence of non-communicable diseases [Diabetes 16.4%, Hypertension (40.6%), and overweight/obesity (63.5%)]. These can be attributed to the low rates of physical activities (43.8%) and poor dietary habits (34%). Passive smoking is common at home and the work place. However, Active smoking is very common (49.6%) and seems to start at a young age (19 years). Hypercholesterolemia affected 20.9% of the adult population. The Diabetes Care Guidelines were developed using the “derived” model by adapting regional and international guidelines to the local needs of Libyan patients. They included guidance on diagnosis, evaluation and clinical management in addition to the organizational issues. It remains for all concerned to get together to meet the challenges of non-communicable diseases and translate the guidelines to clinical practice in the real world.
[ABSTRACT]   Full text not available  [PDF] [CITATIONS]
  1,095 135 7
Molybdenum cofactor deficiency: Report of a new case and literature review
Waseem M Fathalla, Khalid A Mohamed, Elamin Ahmed
May-June 2010, 2(3):133-138
We report a case of genetically confirmed molybdenum cofactor deficiency in an infant presenting with difficult to control neonatal seizures, and a severe cystic leukoencephalopathy on brain magnetic resonance imaging (MRI). This is a rare disease entity that can be easily missed or confused with hypoxic ischemic encephalopathy. Raising awareness regarding this condition has significant implications regarding genetic counseling, prognostication, and possibly medicolegal liability. We report a case confirmed by genetic testing that revealed a mutation previously unreported to the best of our knowledge. We discuss the clinical presentation, imaging findings, and review the literature on this under-recognized disease.
[ABSTRACT]   Full text not available  [PDF] [CITATIONS]
  1,069 120 1
Technical note: Minimally invasive ‘second look’ in the era of laparoscopic surgery
Keith Hussey, Kieran Chircop, Abdulmajid Ali
May-June 2010, 2(3):129-132
Benefits associated with minimally invasive surgery, in both elective and emergency practice, are well established. In recent years, laparoscopic surgery has been embraced, and has gained increasing popularity. We describe a modification of a previously described technique in the context of the ‘second look’ in the era of laparoscopic surgery. A seventy year old patient with type one respiratory failure presented with an acute abdomen. Pre-operative imaging suggested mesenteric ischaemia. A decision was made to proceed with laparoscopic surgical intervention. An infarcted small bowel segment was identified and resected. A primary anastomosis was constructed, but in view of the underlying pathological process, it was felt that a ‘second look’ was required. This was facilitated by leaving an 11mm port in left lower quadrant after the primary procedure, so that twenty four hours post-operatively the anastomosis could be inspected. The concept of the ‘second look’ is well established in the context of mesenteric ischaemia. A laparoscopic ‘second look’ following open surgery has been previously described. We have embraced the ‘second look’ concept and we were able to perform both procedures in a minimally invasive fashion.
[ABSTRACT]   Full text not available  [PDF]
  1,051 120 -
Plasma zinc and copper levels in children of families with history of cardio-vascular disease
S Omer Sheriff, Dhastagir Sultan Sheriff, Abdalla M Jarari
May-June 2010, 2(3):125-128
Zinc and copper are beneficial to health, growth and development, and also for the prevention of cardiovascular- disease (CVD) with regard to improved dietary habits as a preliminary step in CVD prevention. This study was conducted among 2-18-year old children with significant family risk for premature CVD in comparison to controls. Materials and Methods: One hundred randomly selected children of parents who had premature myocardial infarctions were included in the study. The controls were 100 individuals randomly selected from the case group's neighbors and matched for age, sex and socioeconomic status. A four-day food record questionnaire was used to assess zinc and copper intakes Results: The daily average intake of zinc was significantly lower in the case than in the control group (6.89±2.97 vs. 8.30±2.45 mg, P=0.047). The mean serum zinc level was not significantly different between both groups (82.12±14.1 vs. 92.26±23.7 μg/dL, P>0.05). The daily intake and serum level of copper were not significantly different between the case and the control groups. No case of copper deficiency was found. The mean systolic blood pressure was not significantly different between the zinc-deficient and zinc-sufficient subjects. Although the mean diastolic blood pressure of the former was higher than the latter, there was no statistically significant difference. About 23.7% of all studied sample had mild to moderate degrees of failure to thrive, with significantly lower daily intake and serum zinc level than other subjects (5.41±1.06 mg, 82.09±12.74 μg/dL vs. 6.89±2.14 mg, 99.25±27.15 μg/dL, respectively, P<0.05). Conclusion: We propose that children, especially those with significant family risk of premature CVD, place increased emphasis on the consumption of foods rich in zinc.
[ABSTRACT]   Full text not available  [PDF]
  1,028 106 -
The pattern of occurrence of oral squamous cell carcinoma in Libya
Mohamed A Jaber, Salem H Abu Fanas
May-June 2010, 2(3):105-110
The objective of this study is to describe aspects of oral squamous cell carcinoma (OSCC) in a cohort of hospital patients in Libya. The patterns of clinical presentation of oral squamous OSCC in 122 Libyan patients from 1979-2004 were retrospectively analysed. Men were affected more often than women with the average age at presentation 53 years. Just over half the patients had symptoms for more than six months prior to presentation. The tongue and floor of the mouth were the most commonly affected sites. In 30.3% of patients the OSCC presented as an ulcer, in 20.4% as a swelling, and in 19% as a white patch. The majority of the patients had stage III or IV disease when first examined. Nearly 80% of the patients were tobacco smokers. It was concluded that the pattern of clinical occurrence of OSCC in Libya was similar to previous reports from Western Europe and Asia. The results of the present study highlight the need for an appropriate strategy to prevent OSCC and reduce delays in the diagnosis and treatment of such disease in Libya.
[ABSTRACT]   Full text not available  [PDF] [CITATIONS]
  1,011 123 3
Relationship of diabetes control to periodontal status in type 1 diabetic patients
Salem Abufanas, Suleiman Omer, Mohamed Jaber, Sam Thomas
May-June 2010, 2(3):111-117
Objectives: To find the relationship of diabetes control to periodontal status in type 1 diabetic patients and to compare the severity of periodontal disease of type-1 diabetics (IDDM) and non-diabetics and to further compare the periodontal status in the controlled and uncontrolled diabetics in a group of Libyan population to form a baseline reference for future researches. Materials & Methods: The periodontal status of 30 diabetic and 30 control subjects was examined. The diabetic group was further subdivided into controlled and uncontrolled groups. Results: There were significant differences between the whole diabetic group and the control group in terms of the periodontal status. A comparison between the controls and diabetic subgroups revealed that controlled diabetic patients had poor periodontal health than controls. Within the diabetic subgroups, there was more loss of attachment in the uncontrolled diabetics. Conclusion: Better periodontal health in the diabetic patients may be related to good control of diabetes, indicating better resistance of the periodontium.
[ABSTRACT]   Full text not available  [PDF]
  921 111 -
The ECG quiz: “Zebra!”
Fathi I Ali
May-June 2010, 2(3):139-141
Full text not available  [PDF]
  783 108 -
Medical ethics in the developing world: Time to strengthen the rules
Elhadi H Aburawi
May-June 2010, 2(3):103-104
Full text not available  [PDF]
  693 102 -