Advanced Search
Users Online: 203
Home
About us
Editorial board
Ahead of print
Current issue
Search
Archives
Submit article
Instructions
Contacts
Reader Login
Export selected to
Endnote
Reference Manager
Procite
Medlars Format
RefWorks Format
BibTex Format
Access statistics : Table of Contents
2011| May-June | Volume 3 | Issue 3
Online since
July 17, 2017
Archives
Previous Issue
Next Issue
Most popular articles
Most cited articles
Show all abstracts
Show selected abstracts
Export selected to
Viewed
PDF
Cited
ARTICLES
Ionically cross-linked chitosan/tripolyphosphate microparticles for the controlled delivery of pyrimethamine
Emmanuel Chinedum Ibezim, Cristina Tristao Andrade, Cristina Marcia, Bianca Barretto, Damian Chukwu Odimegwu, Felipe Forte De Lima
May-June 2011, 3(3):77-88
DOI
:10.4103/1947-489X.210876
Chitosan ionically cross-linked with tripolyphosphate at regulated temperatures (25°C, 40°C, and 50°C) and varying cross-linking times (30 min, 2 h and 4 h respectively) was used to form microparticles employed in the encapsulation of pyrimethamine, an antiprotozoal drug. The yields, equilibrium moisture contents, percentage concentration, swelling characteristics, entrapment efficiency, release properties, infrared spectroscopy, and differential scanning calorimetry of the formulated microparticles were evaluated. The yield of microparticles produced ranged from 0.3515 to 0.7749 g per 100 ml of cross linking solution. The products possessed relatively little amounts of moisture (0.22 − 3.04 % w/v). The entrapment efficiencies ranged from 25.55 to 99 % with the product formed at ambient temperature and cross linking time of 30 min possessing the highest efficiency. The swelling kinetics on the microcapsules revealed that all the products swelled in the various pH media following mainly anomalous sorption mechanism with a few diffusion controlled mechanism. The greatest swellings however occurred at the swelling medium of pH 1 while the least swelling occurred at pH 7. Spectral and differential scanning calorimetric properties of the chitosan used in the study were consistent with those of standard chitosan. The infrared spectroscopy and differential scanning calorimetry of the products confirmed that encapsulation actually occurred with the spectral characters of the products differing from those of the parent constituents (chitosan, tripolyphosphate and pyrimethamine). Based on these factors, tripolyphosphate cross-linked chitosan microparticles present a suitable matrix for the controlled release of pyrimethamine.
[ABSTRACT]
Full text not available
[PDF]
[CITATIONS]
1,145
195
15
Community pharmacists' knowledge, attitude and practice towards diabetes care in Tripoli, Libya
Adnan F Bisheya, Salma A.B El-Mijbri, Salem A Beshyah, Ibrahim Sherif
May-June 2011, 3(3):89-95
DOI
:10.4103/1947-489X.210877
Background:
Significant benefit from involving community pharmacists in diabetes management has been demonstrated. This study was undertaken to evaluate the knowledge and attitudes of community pharmacists to diabetes care in Tripoli, Libya.
Materials and Methods:
One hundred and forty six conveniently selected community pharmacists were surveyed by 2 questionnaires. The first documented the available services and pharmacists' perceived role in diabetes care. The second evaluated the pharmacists' diabetes knowledge based on a validated 23 item questionnaire, the “Arabic Short Diabetes Knoledge Test” (ASDKT).
Results:
The survey demonstrated inconsistent supply of different diabetic medications. Insulin was not available throughout most of the pharmacies, whereas Sulphonylureas and Metformin were more readily available. Urine and blood glucose testing strips and glucose meters were available irregularly in about half of the pharmacies. The role of pharmacists in diabetes care was mainly viewed as supply and dispensing, dispensing and instruction and help and support. Diabetes educational activities offered by the pharmacists included providing information on availability of diabetes-related items, counseling on the use of drugs, instruction on use of glucose meters and answering general questions about diabetes. The information provided was rated as good and adequate by almost three quarters of the participants. The median ASDKT's overall score for all questions was 16/23. General diabetes information score was 9/15 and for insulin therapy-specific questions was 7/8. The sources of information used in diabetic education were books and journals, through learning from colleagues, product literature and attending lectures were thought to be helpful. Pharmacists were prepared to enhance their education by meetings and lectures, Journals and books, audiotapes and self-education.
Conclusions:
Community pharmacists offer a readily accessible potential resource for diabetes education. Our survey of practicing pharmacists, elucidated their readiness to participate in a multidisciplinary diabetes management team. Incorporation of community pharmacists in any national diabetes educational program is necessary.
[ABSTRACT]
Full text not available
[PDF]
[CITATIONS]
1,151
155
3
COMMENTARY
Spectrum of respiratory diseases in the middle east
Abdelkarim Waness, Yaser Abu El Sameed
May-June 2011, 3(3):96-98
DOI
:10.4103/1947-489X.210878
Full text not available
[PDF]
718
110
-
CASE REPORT
Clinical vignettes: “Ants on diapers” a modern twist on an old theme
Salah Abdelsalam Elhasi
May-June 2011, 3(3):99-100
DOI
:10.4103/1947-489X.210879
Full text not available
[PDF]
685
91
-
© Ibnosina Journal of Medicine and Biomedical Sciences | Published by Wolters Kluwer -
Medknow
Sitemap
|
What's New
|
Feedback
|
Disclaimer
|
Privacy Notice
Online since 27
th
Oct, 2016