Ibnosina Journal of Medicine and Biomedical Sciences

ORIGINAL ARTICLE
Year
: 2017  |  Volume : 9  |  Issue : 5  |  Page : 136--139

Are oral hypoglycemic agents suitable as the first-line treatment for newly diagnosed type 2 diabetes in patients with severe hyperglycemia?


Abbas Ali Mansour, Ali Hussein Ali Alhamza, Ibrahim Abbood Zaboon 
 Department of Medicine, Basrah College of Medicine; Faiha Specialized Diabetes, Endocrine, and Metabolism Center, Basrah, Iraq

Correspondence Address:
Abbas Ali Mansour
Faiha Specialized Diabetes, Endocrine, and Metabolism Center, P.O. Box 142, Hattin Post Office, Basrah 61013
Iraq

Objectives: To investigate if starting oral antihyperglycemic agent was enough to achieve the target glycated hemoglobin (HbA1c) in patients with newly diagnosed type 2 diabetes mellitus (T2DM), despite severe hyperglycemia, with or without symptoms. Patients and Methods: This was a retrospective patient data analysis for patients with newly diagnosed T2DM during January to December 2013. At baseline and after 3 months, HbA1c was measured. All patients started a diet and lifestyle changes in addition to oral hypoglycemic agents. Results: The enrolled patients were 764 in number. Of them, 331 (42.9%) achieved the target HbA1c <7% by oral hypoglycemic agents after 3 months, regardless of the treatment used. Multivariable logistic regression analysis showed that only presenting fasting plasma glucose <150 mg (odds ratio [OR] 2.193, 95% confidence interval [CI] 1.297–3.709) and drug treatment (OR 1.320, 95% CI 1.100–1.585) were the independent variables associated with achieving the glycemic target. Conclusions: Using antihyperglycemic agents as the first line for new T2DM, 42.9% patients can achieve target glycemic control. Even those with gross glycemic abnormalities, more than 60%, can achieve target glycemic control using diet, lifestyle change, and metformin. Prospective trials are needed to confirm such findings.


How to cite this article:
Mansour AA, Alhamza AH, Zaboon IA. Are oral hypoglycemic agents suitable as the first-line treatment for newly diagnosed type 2 diabetes in patients with severe hyperglycemia?.Ibnosina J Med Biomed Sci 2017;9:136-139


How to cite this URL:
Mansour AA, Alhamza AH, Zaboon IA. Are oral hypoglycemic agents suitable as the first-line treatment for newly diagnosed type 2 diabetes in patients with severe hyperglycemia?. Ibnosina J Med Biomed Sci [serial online] 2017 [cited 2022 Jul 4 ];9:136-139
Available from: http://www.ijmbs.org/article.asp?issn=1947-489X;year=2017;volume=9;issue=5;spage=136;epage=139;aulast=Mansour;type=0