Advanced Search
  • Users Online: 215
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Contacts Login 
ORIGINAL ARTICLE
Year : 2021  |  Volume : 13  |  Issue : 2  |  Page : 60-66

Clinical characteristics of igG4-related disease in the United Arab Emirates: A retrospective single-center study

Rajaie Namas1, Mohamed Elarabi1, Safa Hegazin2, Abhay Joshi1, Fulvio Salvo3, Imad Jassim4, Muriel Ghosn5, Nizar Attallah5, Priti Joshi6, Esat Memisoglu7, Waleed Hassen8, Jamal Al-Saleh9, Mohamed Abuzakouk3
1 Department of Internal Medicine, Division of Rheumatology, Cleveland Clinic Abu Dhabi, Abu Dhabi, UAE
2 Department of Internal Medicine, Division of Hospital Medicine, Cleveland Clinic Abu Dhabi, Abu Dhabi, UAE
3 Department of Medicine, Division of Allergy and Immunology, Cleveland Clinic Abu Dhabi, Abu Dhabi, UAE
4 Department of Medicine, Division of Rheumatology, Tawam Hospital, Al-Ain, UAE
5 Department of Internal Medicine, Division of Nephrology, Cleveland Clinic Abu Dhabi, Abu Dhabi, UAE
6 Department of Medicine, Division of Pathology, Cleveland Clinic Abu Dhabi, Abu Dhabi, UAE
7 Department of Radiology, Cleveland Clinic Abu Dhabi, Abu Dhabi, UAE
8 Department of Medicine, Division of Urology, Cleveland Clinic Abu Dhabi, Abu Dhabi, UAE
9 Department of Internal Medicine, Division of Rheumatology, Dubai Hospital, Dubai, UAE

Correspondence Address:
Dr. Rajaie Namas
Department of Internal Medicine, Division of Rheumatology, Cleveland Clinic Abu Dhabi, Abu Dhabi
UAE
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1947-489X.320341

Rights and Permissions

Background: Demographic and clinical data of IgG4-related disease affecting solely the native population of the UAE, known as Emiratis, does not exist in the literature. Aim: To explore the demographic and clinical characteristics of IgG4-related disease in a well-defined population of Emirati patients attending Cleveland Clinic Abu Dhabi, a large tertiary center in the Middle East. Patients and Methods: The data presented is part of a retrospective cohort study, in which 15 Emirati patients with IgG4-related disease (IgG4-RD) were evaluated over 5 years from April 2015 to September 2020 at the rheumatology outpatient clinic at Cleveland Clinic Abu Dhabi. The demographic and clinical data were recorded. Descriptive statistics of the variables were applied. Results: Fifteen Emirati patients with an established diagnosis of IgG4-RD were assessed. There was a male predominance (53%) with a median age at the time of diagnosis of 47 ± 11.2 years. A 6-year lag period was noted from the initial presentation until a diagnosis of IgG4-RD was established. The most frequent comorbidities observed were hematological conditions (63%), hypertension (47%), diabetes mellitus (40%), and gastroesophageal reflux disease (40%). An elevated serum IgG4 was observed in the majority of patients at the initial presentation. Rheumatoid factor was detected in 13% and low titer of immunofluorescence antinuclear antibody in 7%. 86% of patients had a tissue biopsy with marked lymphocytic and plasmacytic infiltration being the most reported finding in 86%. Methotrexate, azathioprine, and rituximab were the most frequently prescribed disease-modifying agents. Conclusion: We report the first comprehensive analysis on a small cohort of Emirati patients with IgG4-RD. We describe disease features unique to UAE patients and demonstrate that IgG4-RD has a significant disease burden. Our results underscore the need for the IgG4-RD UAE-wide national registry to improve the quality of care of these patients.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed581    
    Printed6    
    Emailed0    
    PDF Downloaded68    
    Comments [Add]    

Recommend this journal

 

© Ibnosina Journal of Medicine and Biomedical Sciences | Published by Wolters Kluwer - Medknow
Online since 27th Oct, 2016