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ARTICLE
Year : 2014  |  Volume : 6  |  Issue : 1  |  Page : 14-18

Deferasirox versus deferoxiamine for the treatment of transfusional iron overload in patients with β-thalassemia major


Department of Internal Medicine, Faculty of Medicine, Assiut University, Assiut, Egypt

Correspondence Address:
Osama A Ibrahiem
Department of Internal Medicine, Faculty of Medicine, Assiut University, Assiut
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1947-489X.210350

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Background: Many patients with transfusional iron overload are at risk of progressive organ dysfunction and early death. Poor compliance with iron chelators is believed to be a major contributing factor. Objectives: The aim of this study is to evaluate the efficacy of Deferasirox in comparison with Deferoxiamine for the treatment of transfusional iron overload in patients with β-thalassemia major. Patients and Methods: We evaluated the oncedaily Deferasirox for 48 weeks in forty patients (older than 2 years) who had β-thalassaemia major with evidence of iron overload. Some had been previously treated with chelating agents. Most patients began treatment with Deferasirox 10 mg/kg/ day and may be increased to 30 mg/kg/day. Serum ferritin level was assessed before and after beginning of Deferasirox treatment at 3 months interval for 48 weeks. Results: Deferasirox was associated with mild adverse events on most occasions. The mean serum ferritin level decreased significantly in all patients treated with Deferasirox compared to those on Deferoxiamine. Conclusions: Administration of Deferasirox as an oral drug may be preferable and more effective than the parentral iron chelating therapy with better compliance and no inconvenience of parenteral infusion regimens.


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