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COMMENTARY
Year : 2013  |  Volume : 5  |  Issue : 4  |  Page : 240-242

Metformin, the remarkable and unique antidiabetic agent


Whipps Cross University Hospital, Barts Health NHS Trust, London, United Kingdom

Correspondence Address:
Abdulfattah Ali Lakhdar
Whipps Cross University Hospital, Barts Health NHS Trust, London
United Kingdom
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1947-489X.210551

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In the current issue of this Journal, Fiad and colleagues thoughtfully reviewed in detail the role of metformin in current clinical practice and highlighted the additional effects of metformin independent of the glycemic action of the drug. The review is comprehensive, up to date and is extensively supported by the literature. Metformin remains the first drug of choice in patients diagnosed with type 2 diabetes. Its vascular protection actions are particularly interesting though not yet fully understood. Its antineoplastic actions are very exciting. The authors clarify the issues of gastrointestinal side effects and renal limitations of its use and give practical ways of minimizing the potential loss of benefit to all treated patients.


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